Gene Silencing

  • ​Chiu YL and Rana TM. (2002) RNAi in human cells: basic structural and functional features of small interfering RNA. Molecular Cell, 10, 549-561. DOI: 10.1016/S1097-2765(02)00652-4
  • Chiu YL and Rana TM. (2003) siRNA function in RNAi: a chemical modification analysis. RNA, 9, 1034-48
  • Brown KM, Chu CY, and Rana TM. (2005) Target accessibility dictates the potency of human RISC. Nature Structural & Molecular Biology, 12, 469-470. DOI: 10.1038/nsmb931
  •  Chu C and Rana TM. (2006) Translation repression in human cells by micro RNA-induced gene silencing requires RCK/p54. PLos Biology, 4, e210. DOI: 10.1371/journal.pbio.0040210
  •  Baigude H, McCarroll J, Yang CS, Swain PM, and Rana TM. (2007) Design and creation of new nanomaterials for therapeutic RNAi. ACS Chemical Biology, 2, 237-241. DOI: 10.1021/cb7000582
  •  Rana TM. (2007) Illuminating the silence: understanding the structure and function of small RNAs. Nature Reviews in Molecular and Cellular Biology, 8, 23-36. DOI: 10.1038/nrm2085
  •  Su J, Baigude H, McCarroll J, and Rana TM. (2011) Silencing microRNA by interfering nanoparticles in mice. Nucleic Acids Research, 39, e38. DOI: 10.1093/nar/gkq1307
  •  Li Z and Rana TM. (2014). Therapeutic targeting of microRNAs: current status and future challenges. Nature Reviews Drug Discovery, 13, 622-638.  DOI: 10.1038/nrd4359